Piecemeal microautophagy of the nucleus

Across TCGA cell cohorts, RNA activity of the Piecemeal microautophagy of the nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG9A, NSA2, and ZNF681, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Piecemeal microautophagy of the nucleus activity versus ATG9A in LUNG_SCLC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATG9A →	+0.870	+0.436	.004	<.001	3	5
BLOOD_Myeloma	NSA2 →	-0.714	-0.319	.005	<.001	3	3
LUNG_SCLC	ZNF681 →	-1.059	-0.422	.002	.003	3	3
BREAST	PLA2G4F →	-1.696	-0.362	<.001	<.001	3	3
BREAST	MSMO1 →	+0.747	+0.236	.008	.007	3	3
OESOPHAGUS	UBTF →	+0.754	+0.337	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034727 vs ATG9A — LUNG_SCLC

Explore this scatter interactively →