Response to luteinizing hormone

Across TCGA pan-cancer cohorts, RNA activity of the Response to luteinizing hormone pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and KIRP, show the opposite pattern, with lower activity in tumor tissue.

UCEC, KIRP, and THCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
UCEC	All	All	−0.170	<.001	8	view →
KIRP	Male	All	−0.066	<.001	8	view →
THCA	All	All	+0.035	<.001	8	view →
KICH	Female	All	−0.102	<.001	7	view →
LIHC	All	All	+0.030	<.001	7	view →
BLCA	Male	All	−0.089	.001	6	view →
LUAD	Female	III,IV	−0.085	<.001	6	view →
BRCA	Female	All	−0.039	<.001	6	view →
LUSC	Female	All	−0.108	<.001	5	view →
CHOL	All	All	+0.092	.008	2	view →
PRAD	All	All	−0.054	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0034699–UCEC

Open the UCEC breakdown →