Response to gonadotropin

Across TCGA cell cohorts, RNA activity of the Response to gonadotropin pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGFR1OP2, SRM, and SOS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FGFR1OP2 grouped by Response to gonadotropin-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FGFR1OP2 →	+1.013	+0.363	.005	.002	3	4
BONE	SRM →	+1.071	+0.545	.002	.001	3	4
OVARY	SOS2 →	+0.657	+0.297	.002	<.001	3	4
OVARY	BAZ1A →	+0.852	+0.263	<.001	.001	3	4
BLOOD_Leukemia	TMEM60 →	+0.848	+0.395	.001	.004	3	3
BLOOD_Leukemia	ZBTB8OS →	+0.617	+0.350	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FGFR1OP2 by Response to gonadotropin activity — PANCREAS

Explore this box plot interactively →