Response to prostaglandin

Across TCGA cell cohorts, RNA activity of the Response to prostaglandin pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARMCX3, FBXO2, and UBE2L6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARMCX3 grouped by Response to prostaglandin-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ARMCX3 →	-1.228	-0.425	.009	.007	2	4
OVARY	FBXO2 →	-2.749	-0.784	.002	.007	3	3
OVARY	UBE2L6 →	-1.310	-0.636	.006	.003	3	3
BLOOD_Myeloma	MFSD4A →	-1.110	-1.425	.001	.008	3	3
LARGE_INTESTINE	IL1R1 →	-1.093	-0.656	.001	.005	3	3
LARGE_INTESTINE	NHP2 →	+0.501	+0.525	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARMCX3 by Response to prostaglandin activity — BREAST

Explore this box plot interactively →