Response to prostaglandin

Across TCGA cell cohorts, RNA activity of the Response to prostaglandin pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NELFA, GCN1, and GNAQ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to prostaglandin activity versus NELFA in LARGE_INTESTINE (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NELFA →	-0.401	-0.342	.005	.008	3	5
OVARY	GCN1 →	-0.661	-0.329	.007	.005	2	6
BLOOD_Leukemia	GNAQ →	+1.009	+0.474	.001	.006	3	4
BREAST	UBAC1 →	-0.723	-0.240	.002	.005	3	4
BREAST	EXOSC2 →	-0.765	-0.240	.003	.002	3	4
OVARY	SURF6 →	-0.646	-0.322	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034694 vs NELFA — LARGE_INTESTINE

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