Nucleobase-containing small molecule catabolic process

Across TCGA patient cohorts, RNA activity of the Nucleobase-containing small molecule catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK10, IFI35, and SKAP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing small molecule catabolic process activity versus DOCK10 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOCK10 →	+0.402	+0.050	.002	.001	3	8
OV	IFI35 →	+0.646	+0.051	<.001	<.001	3	8
BRCA	SKAP2 →	+0.515	+0.045	<.001	<.001	3	7
BRCA	WIPF1 →	+0.414	+0.033	<.001	.001	3	7
GBM	CCDC88B_S597 →	+0.766	+0.066	<.001	.001	3	7
OV	AIF1 →	+0.785	+0.058	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034656 vs DOCK10 — OV

Explore this scatter interactively →