Nucleobase-containing small molecule catabolic process

Across TCGA patient cohorts, RNA activity of the Nucleobase-containing small molecule catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD40, CD274, and CD53, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase-containing small molecule catabolic process activity versus CD40 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD40 →	+0.775	+0.181	<.001	<.001	3	8
BRCA	CD274 →	+0.915	+0.220	<.001	<.001	3	7
GBM	CD53 →	+0.908	+0.229	<.001	<.001	3	7
HNSC	CYTH4 →	+0.579	+0.167	.003	<.001	3	6
BRCA	IL21R →	+0.852	+0.212	<.001	<.001	3	6
BRCA	SLC7A7 →	+0.704	+0.196	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034656 vs CD40 — BRCA

Explore this scatter interactively →