Nucleobase-containing small molecule catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleobase-containing small molecule catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TONSL, USP51, and TBC1D20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TONSL grouped by Nucleobase-containing small molecule catabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TONSL →	-1.088	-1.056	.001	.003	3	4
URINARY_TRACT	USP51 →	+0.433	+1.986	.003	<.001	3	4
LIVER	TBC1D20 →	+0.752	+1.647	.008	<.001	3	4
URINARY_TRACT	CEP120 →	+0.846	+1.744	.008	<.001	3	4
URINARY_TRACT	EID2B →	+1.522	+1.652	.001	<.001	3	4
LIVER	PHAX →	+0.726	+1.639	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TONSL by Nucleobase-containing small molecule catabolic process activity — KIDNEY

Explore this box plot interactively →