Cortisol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Cortisol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA2, STARD10, and PARVA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortisol biosynthetic process activity versus HSPA2 in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSPA2 →	+0.888	+0.073	<.001	<.001	2	8
BRCA	STARD10 →	+0.736	+0.069	<.001	<.001	3	6
CCRCC	PARVA →	+0.385	+0.067	<.001	.007	3	6
CCRCC	BGN →	+0.990	+0.090	<.001	<.001	3	6
CCRCC	HMCN1 →	+0.520	+0.082	<.001	<.001	3	6
CCRCC	OLFML3 →	+0.479	+0.053	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034651 vs HSPA2 — BRCA

Explore this scatter interactively →