Cortisol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Cortisol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR2C, HADHAP2, and MILR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortisol biosynthetic process activity versus FCGR2C in CCRCC (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FCGR2C →	+0.632	+0.608	.003	.001	3	4
HNSC	HADHAP2 →	+0.530	+0.455	.006	.008	3	3
BRCA	MILR1 →	+0.561	+0.659	.001	<.001	3	3
BRCA	MFNG →	+0.522	+0.509	.002	.002	3	3
CCRCC	LINC01094 →	+0.471	+0.506	.001	.007	3	3
OV	GTSF1L →	-0.154	-0.742	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034651 vs FCGR2C — CCRCC

Explore this scatter interactively →