Cortisol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Cortisol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOL9, HYPK, and HESX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOL9 grouped by Cortisol biosynthetic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NOL9 →	+0.705	+1.307	<.001	<.001	3	4
LARGE_INTESTINE	HYPK →	+0.602	+0.808	.004	<.001	3	4
SKIN	HESX1 →	-0.411	-0.924	<.001	.002	3	4
BREAST	MCIDAS →	+0.792	+0.371	.004	.005	1	5
LUNG_SCLC	NCLN →	+0.657	+1.121	.008	.003	2	4
LUNG_SCLC	GLIS2 →	-1.238	-1.566	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOL9 by Cortisol biosynthetic process activity — PANCREAS

Explore this box plot interactively →