Cortisol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Cortisol biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPT1, PSMB5, and APOH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNPT1 grouped by Cortisol biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PNPT1 →	+0.416	+1.008	<.001	<.001	3	5
SKIN	PSMB5 →	+0.412	+0.793	<.001	.009	3	4
LIVER	APOH →	-0.148	-1.798	.005	.005	3	4
BREAST	MED25 →	+0.073	+0.887	.003	.002	3	4
STOMACH	FOXN1 →	+0.240	+0.799	.006	.009	3	4
BREAST	MMP20 →	+0.116	+0.905	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNPT1 by Cortisol biosynthetic process activity — BREAST

Explore this box plot interactively →