Cortisol metabolic process

Across TCGA patient cohorts, RNA activity of the Cortisol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC88A, TWF2, and HSD11B2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortisol metabolic process activity versus CCDC88A in CCRCC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CCDC88A →	-0.171	-0.069	.006	.004	3	6
BRCA	TWF2 →	-0.199	-0.057	.005	<.001	3	6
CCRCC	HSD11B2 →	+0.507	+0.059	<.001	.008	3	6
PDAC	SEPTIN7_S334 →	-0.437	-0.113	<.001	<.001	3	5
BRCA	STARD10 →	+0.669	+0.058	<.001	<.001	3	5
PDAC	BIN3 →	+0.206	+0.084	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034650 vs CCDC88A — CCRCC

Explore this scatter interactively →