Cortisol metabolic process

pathway activity — cross-omics
GO:0034650Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cortisol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSD11B2, FADD_S194, and NCOA7_S162, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACHSD11B2 →+0.641+0.865<.001<.00133
BRCAFADD_S194 →-0.867-1.600.002<.00133
HNSCNCOA7_S162 →+1.246+0.296<.001<.00133
OVREST_S864 →+0.563+0.875<.001<.00123
GBMSETX_T2474 →-0.434-0.629<.001.00132
LSCCSYNRG_T1016 →+0.362+0.405.002.00332
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration