Cellular response to UV

Across TCGA cell cohorts, RNA activity of the Cellular response to UV pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TESMIN, FHOD3, and COX7A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TESMIN grouped by Cellular response to UV-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TESMIN →	+1.978	+0.125	.002	.002	3	4
LARGE_INTESTINE	FHOD3 →	-1.284	-0.127	.009	.006	3	4
SKIN	COX7A2 →	+0.634	+0.144	.003	<.001	3	4
SKIN	FADD →	+0.586	+0.140	<.001	<.001	3	4
BREAST	RAMAC →	+0.471	+0.129	.009	.004	3	4
OESOPHAGUS	TTLL7 →	+1.702	+0.121	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TESMIN by Cellular response to UV activity — LUNG_SCLC

Explore this box plot interactively →