Glutathione transport

Across TCGA patient cohorts, RNA activity of the Glutathione transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MGST1, MT2A_S58, and XPOT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione transport activity versus MGST1 in GBM (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MGST1 →	+0.994	+0.094	<.001	<.001	3	5
BRCA	MT2A_S58 →	-1.111	-0.043	.003	.004	3	5
LSCC	XPOT →	+0.341	+0.106	<.001	<.001	3	5
UCEC	AKR1C2 →	+1.753	+0.094	<.001	<.001	3	5
LSCC	G6PD →	+0.884	+0.140	<.001	<.001	3	5
LSCC	GCLM →	+0.944	+0.112	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034635 vs MGST1 — GBM

Explore this scatter interactively →