Glutathione transport

Across TCGA cell cohorts, RNA activity of the Glutathione transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC5, ABCC1, and MGST1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione transport activity versus ABCC5 in OESOPHAGUS (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ABCC5 →	+1.833	+0.182	<.001	<.001	3	16
LUNG_NSCLC_LUAD	ABCC1 →	+1.172	+0.126	<.001	<.001	2	14
BLOOD_Myeloma	MGST1 →	+3.038	+0.146	.001	<.001	3	11
KIDNEY	ABCC4 →	+1.580	+0.177	<.001	<.001	3	10
LIVER	SLC13A3 →	-1.823	-0.101	.003	.001	3	9
BLOOD_Leukemia	CCDC47 →	+0.718	+0.127	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034635 vs ABCC5 — OESOPHAGUS

Explore this scatter interactively →