Glutathione transport

Across TCGA cell cohorts, RNA activity of the Glutathione transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXQ1, GSR, and B3GAT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione transport activity versus FOXQ1 in PANCREAS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FOXQ1 →	+2.352	+1.305	.004	.004	3	4
KIDNEY	GSR →	+2.559	+2.115	.003	<.001	3	4
LUNG_NSCLC_LUAD	B3GAT2 →	-0.196	-1.108	.006	.006	3	4
LUNG_NSCLC_LUAD	RIN2 →	-1.266	-0.921	.009	.004	3	4
LUNG_NSCLC_LUAD	UACA →	-1.139	-1.319	.001	<.001	3	4
LUNG_NSCLC_LUAD	ASGR1 →	-0.535	-0.680	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034635 vs FOXQ1 — PANCREAS

Explore this scatter interactively →