Cellular response to unfolded protein

Across TCGA patient cohorts, RNA activity of the Cellular response to unfolded protein pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SEPTIN4_S432, and RPL10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to unfolded protein activity versus RPL5 in BRCA (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.230	-0.042	<.001	<.001	3	7
HNSC	SEPTIN4_S432 →	+0.491	+0.065	.006	.008	3	6
BRCA	RPL10 →	-0.232	-0.031	<.001	<.001	3	6
GBM	SEPTIN4 →	+0.633	+0.040	.002	<.001	3	6
LSCC	FAM207A →	-0.502	-0.041	<.001	<.001	3	6
GBM	HSPA12A →	+0.607	+0.029	.004	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034620 vs RPL5 — BRCA

Explore this scatter interactively →