Cellular response to unfolded protein

Across TCGA cell cohorts, RNA activity of the Cellular response to unfolded protein pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM9, ENO3, and GTF2H4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAM9 grouped by Cellular response to unfolded protein-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ADAM9 →	+1.221	+0.149	.002	<.001	3	4
SOFT_TISSUE	ENO3 →	+3.244	+0.264	.003	.004	3	4
LARGE_INTESTINE	GTF2H4 →	+0.830	+0.245	.002	.002	3	4
LUNG_NSCLC_LUAD	ZNF589 →	+0.540	+0.107	.003	.003	3	4
CNS	FAM117A →	+0.903	+0.198	.004	.004	3	4
BREAST	PGBD1 →	+0.775	+0.105	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAM9 by Cellular response to unfolded protein activity — BREAST

Explore this box plot interactively →