Cellular response to unfolded protein

Across TCGA cell cohorts, RNA activity of the Cellular response to unfolded protein pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP36, C4orf46, and ARHGEF10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to unfolded protein activity versus ZFP36 in LUNG_NSCLC_LUSC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZFP36 →	+2.330	+0.334	.007	<.001	3	6
BREAST	C4orf46 →	-0.671	-0.150	.005	<.001	3	6
LARGE_INTESTINE	ARHGEF10 →	-1.299	-0.131	.003	.004	3	5
STOMACH	GPRIN1 →	-2.598	-0.278	<.001	<.001	3	5
BREAST	FAM210A →	-0.696	-0.156	.002	.001	3	5
BREAST	KIF3C →	-1.523	-0.242	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034620 vs ZFP36 — LUNG_NSCLC_LUSC

Explore this scatter interactively →