Response to laminar fluid shear stress

Across TCGA patient cohorts, RNA activity of the Response to laminar fluid shear stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C15orf48, ADAM9, and TM2D2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to laminar fluid shear stress activity versus C15orf48 in LSCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C15orf48 →	+0.655	+0.368	.002	.005	3	3
LSCC	ADAM9 →	+1.015	+0.626	<.001	.002	3	3
LSCC	TM2D2 →	+0.765	+0.427	<.001	.004	3	3
LSCC	ZBTB18 →	-0.681	-0.691	.003	<.001	3	3
GBM	PPIAP52 →	-0.521	-0.507	<.001	.002	3	3
GBM	EHD4 →	+0.418	+0.563	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034616 vs C15orf48 — LSCC

Explore this scatter interactively →