Response to laminar fluid shear stress

Across TCGA cell cohorts, RNA activity of the Response to laminar fluid shear stress pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NANS, GPN2, and AGO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NANS grouped by Response to laminar fluid shear stress-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NANS →	+0.842	+0.315	<.001	.006	3	4
LUNG_NSCLC_LUAD	GPN2 →	-0.618	-0.284	.001	<.001	3	4
BLOOD_Myeloma	AGO1 →	-0.488	-0.288	.006	.008	3	4
BONE	PEX7 →	+0.847	+0.318	.001	.004	3	3
LUNG_NSCLC_LUAD	LRRC25 →	-0.022	-0.305	.006	.003	3	3
LUNG_NSCLC_LUAD	MERTK →	-1.526	-0.328	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NANS by Response to laminar fluid shear stress activity — BREAST

Explore this box plot interactively →