Cellular response to reactive oxygen species

Across TCGA patient cohorts, RNA activity of the Cellular response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-204P, LINC01714, and LMF1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to reactive oxygen species activity versus RNU6-204P in CCRCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RNU6-204P →	-1.064	-0.256	.003	.001	3	3
OV	LINC01714 →	+0.174	+0.096	.001	.007	3	3
BRCA	LMF1 →	-0.439	-0.132	.009	.006	3	2
PDAC	CLCN3 →	-0.420	-0.170	.002	<.001	3	2
PDAC	MGAT3 →	-1.340	-0.175	.004	.002	3	2
PDAC	MYO5C →	-0.824	-0.212	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034614 vs RNU6-204P — CCRCC

Explore this scatter interactively →