Cellular response to reactive oxygen species

Across TCGA cell cohorts, RNA activity of the Cellular response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTD1, HTRA1, and SRP54, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DTD1 grouped by Cellular response to reactive oxygen species-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DTD1 →	-1.774	-0.236	.005	<.001	2	4
OESOPHAGUS	HTRA1 →	-2.828	-0.189	.001	.003	3	3
BREAST	SRP54 →	+0.568	+0.148	.009	.004	3	3
BLOOD_Myeloma	RIMBP3B →	+0.222	+0.292	.003	<.001	3	3
LUNG_SCLC	ITGA7 →	+1.779	+0.149	.007	.001	3	3
LUNG_SCLC	TACSTD2 →	-0.642	-0.136	.004	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DTD1 by Cellular response to reactive oxygen species activity — OESOPHAGUS

Explore this box plot interactively →