Cellular response to reactive oxygen species

Across TCGA cell cohorts, RNA activity of the Cellular response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC17A9, MORC2, and UBTD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to reactive oxygen species activity versus SLC17A9 in LIVER (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC17A9 →	+3.576	+0.237	.001	.004	3	5
LIVER	MORC2 →	+0.770	+0.234	.001	<.001	3	5
BONE	UBTD1 →	-1.722	-0.094	.002	.004	3	5
LIVER	ENPP2 →	+3.671	+0.206	.004	.005	3	4
LUNG_NSCLC_LUAD	AKAP7 →	+0.822	+0.153	<.001	<.001	3	4
LUNG_NSCLC_LUAD	AKR1C1 →	+4.298	+0.165	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034614 vs SLC17A9 — LIVER

Explore this scatter interactively →