Response to tumor necrosis factor

Across TCGA patient cohorts, RNA activity of the Response to tumor necrosis factor pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP30, PLEKHO2, and ANKRD44, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to tumor necrosis factor activity versus ARHGAP30 in GBM (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP30 →	+0.625	+0.065	<.001	<.001	3	10
OV	PLEKHO2 →	+0.445	+0.040	<.001	<.001	3	10
LSCC	ANKRD44 →	+0.421	+0.043	<.001	<.001	3	10
GBM	RIN3 →	+0.412	+0.051	<.001	<.001	3	9
OV	TLN1 →	+0.417	+0.042	<.001	<.001	3	9
GBM	CORO1A →	+0.622	+0.060	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034612 vs ARHGAP30 — GBM

Explore this scatter interactively →