Response to tumor necrosis factor

Across TCGA cell cohorts, RNA activity of the Response to tumor necrosis factor pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP9, SYT7, and MLPH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to tumor necrosis factor activity versus DUSP9 in LIVER (Pearson r = -0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DUSP9 →	-6.240	-0.478	<.001	<.001	3	5
LIVER	SYT7 →	-1.468	-0.292	.009	.006	3	4
LIVER	MLPH →	+6.155	+0.352	<.001	.001	3	4
LIVER	NAV1 →	+4.160	+0.369	<.001	.001	3	4
LIVER	RPS6KA4 →	+1.168	+0.377	.005	.001	3	4
LIVER	THOC7 →	+0.535	+0.327	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034612 vs DUSP9 — LIVER

Explore this scatter interactively →