Cellular response to heat

Across TCGA patient cohorts, RNA activity of the Cellular response to heat pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITIH3, THBS1, and C1QC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to heat activity versus ITIH3 in CCRCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ITIH3 →	+0.618	+0.032	<.001	<.001	3	7
GBM	THBS1 →	+0.595	+0.028	.001	.006	3	6
GBM	C1QC →	+0.603	+0.042	<.001	<.001	3	6
CCRCC	RIPOR1 →	+0.159	+0.030	<.001	.001	3	5
GBM	SERPING1 →	+0.570	+0.045	.002	<.001	3	5
COAD	THBS2 →	+0.680	+0.019	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034605 vs ITIH3 — CCRCC

Explore this scatter interactively →