Cellular response to heat

Across TCGA cell cohorts, RNA activity of the Cellular response to heat pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTHL1, NDUFAB1, and HSPD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to heat activity versus NTHL1 in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NTHL1 →	+0.857	+0.194	<.001	.001	3	7
KIDNEY	NDUFAB1 →	+1.063	+0.207	.009	.005	3	5
OVARY	HSPD1 →	+0.576	+0.197	<.001	<.001	3	5
OVARY	INO80E →	+0.393	+0.199	.003	<.001	3	5
LUNG_NSCLC_LUAD	TMEM11 →	+0.580	+0.156	.005	.002	3	5
UPPER_AERODIGESTIVE_TRACT	COX15 →	+0.805	+0.183	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034605 vs NTHL1 — LIVER

Explore this scatter interactively →