Tooth mineralization

Across TCGA patient cohorts, RNA activity of the Tooth mineralization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB39B, SEPTIN1, and LY9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tooth mineralization activity versus RAB39B in UCEC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAB39B →	-0.559	-0.636	.002	.001	3	6
HNSC	SEPTIN1 →	-0.644	-0.480	.004	.003	3	4
LUAD	LY9 →	-0.481	-0.598	.007	<.001	3	4
UCEC	IFNG-AS1 →	-0.945	-0.683	<.001	.002	3	4
GBM	CSTF3-DT →	-0.228	-0.362	<.001	.002	3	4
GBM	KLRG1 →	-0.332	-0.248	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034505 vs RAB39B — UCEC

Explore this scatter interactively →