Tooth mineralization

Across TCGA cell cohorts, RNA activity of the Tooth mineralization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC1, DLG4, and RRM2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDC1 grouped by Tooth mineralization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SDC1 →	-2.506	-0.617	.003	<.001	3	4
SKIN	DLG4 →	+1.686	+1.279	<.001	<.001	3	4
SKIN	RRM2B →	+1.243	+1.146	<.001	.002	3	4
OVARY	CUL5 →	+1.030	+1.074	<.001	<.001	3	4
BREAST	CEP290 →	+0.837	+0.874	<.001	.001	3	3
BREAST	MDP1 →	+0.738	+0.936	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDC1 by Tooth mineralization activity — PANCREAS

Explore this box plot interactively →