Tooth mineralization

Across TCGA cell cohorts, RNA activity of the Tooth mineralization pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAV, COG2, and TLN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGAV grouped by Tooth mineralization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ITGAV →	+0.569	+0.311	<.001	<.001	3	5
LIVER	COG2 →	+0.306	+0.476	.009	.003	3	4
LIVER	TLN1 →	+0.702	+0.536	.008	.001	3	4
LIVER	TEAD1 →	+0.556	+0.339	.003	.007	3	4
SOFT_TISSUE	ZNF250 →	-0.483	-0.242	.001	<.001	3	4
SOFT_TISSUE	TSC2 →	-0.333	-0.246	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGAV by Tooth mineralization activity — CNS

Explore this box plot interactively →