Tooth mineralization

Across TCGA cell cohorts, RNA activity of the Tooth mineralization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM3, FCHO1, and DNMBP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tooth mineralization activity versus MCM3 in PANCREAS (Pearson r = -0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MCM3 →	-1.103	-1.785	.008	<.001	3	3
PANCREAS	FCHO1 →	-2.670	-1.952	.002	<.001	3	3
OVARY	DNMBP →	-1.775	-1.447	.009	.001	3	3
OVARY	DOCK5 →	-1.725	-1.324	.001	<.001	3	3
BREAST	SPIRE1 →	+0.718	+1.283	.004	.004	3	3
CNS	SLF1 →	-0.884	-1.086	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034505 vs MCM3 — PANCREAS

Explore this scatter interactively →