Protein localization to chromosome

Across TCGA patient cohorts, RNA activity of the Protein localization to chromosome pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPL, TPP2, and MMS22L, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to chromosome activity versus CENPL in DLBC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	CENPL →	+1.045	+0.052	<.001	<.001	3	34
UVM	TPP2 →	+1.410	+0.030	<.001	<.001	3	34
DLBC	MMS22L →	+0.726	+0.052	<.001	<.001	3	34
LIHC	CIP2A →	+1.325	+0.042	<.001	<.001	3	34
LIHC	NEMP1 →	+1.251	+0.038	<.001	<.001	3	34
UVM	MTBP →	+1.227	+0.040	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034502 vs CENPL — DLBC

Explore this scatter interactively →