Protein localization to chromosome

Across TCGA cell cohorts, RNA activity of the Protein localization to chromosome pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BATF, DHX33, and NUP88, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BATF grouped by Protein localization to chromosome-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	BATF →	+2.659	+0.188	.006	.003	3	5
URINARY_TRACT	DHX33 →	-1.033	-0.278	.009	.003	3	5
LARGE_INTESTINE	NUP88 →	-0.548	-0.119	.009	.005	3	5
OESOPHAGUS	ZNF121 →	-0.987	-0.105	<.001	<.001	3	5
BLOOD_Myeloma	CIT →	-0.695	-0.163	.002	.005	3	4
PANCREAS	KAT6B →	-0.980	-0.233	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BATF by Protein localization to chromosome activity — PANCREAS

Explore this box plot interactively →