Protein localization to chromosome

Across TCGA cell cohorts, RNA activity of the Protein localization to chromosome pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCC2, HCFC1, and MVP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to chromosome activity versus RCC2 in LUNG_SCLC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RCC2 →	+0.557	+0.247	<.001	<.001	3	8
BLOOD_Leukemia	HCFC1 →	+0.750	+0.171	<.001	<.001	3	8
SOFT_TISSUE	MVP →	-2.759	-0.220	.001	.001	3	7
LUNG_NSCLC_LUSC	RRAS →	-3.002	-0.215	.003	.002	3	7
LUNG_SCLC	H2AX →	+1.067	+0.275	.005	.003	3	7
LUNG_SCLC	CDK5RAP2 →	+0.735	+0.263	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034502 vs RCC2 — LUNG_SCLC

Explore this scatter interactively →