Late endosome to Golgi transport

Across TCGA patient cohorts, RNA activity of the Late endosome to Golgi transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S121, DDX21, and DDX21_S89, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to Golgi transport activity versus DDX21_S121 in LSCC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DDX21_S121 →	-0.556	-0.063	<.001	<.001	3	7
COAD	DDX21 →	-0.465	-0.043	<.001	<.001	3	6
LUAD	DDX21_S89 →	-0.700	-0.059	.005	.002	3	6
OV	WDR43_S77 →	-0.768	-0.034	<.001	.002	3	6
BRCA	ABR →	+0.191	+0.028	.003	.008	3	5
BRCA	MYO1C →	+0.400	+0.038	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034499 vs DDX21_S121 — LSCC

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