Late endosome to Golgi transport

Across TCGA patient cohorts, RNA activity of the Late endosome to Golgi transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIRC1, EAF1, and TICAM1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to Golgi transport activity versus DIRC1 in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DIRC1 →	+0.387	+0.261	.001	<.001	3	3
COAD	EAF1 →	-0.428	-0.151	.003	.005	3	3
CCRCC	TICAM1 →	+0.381	+0.148	<.001	<.001	3	3
CCRCC	HOXC6 →	+0.409	+0.187	.001	<.001	3	3
PDAC	FOXD2-AS1 →	+0.312	+0.150	.007	.009	3	3
PDAC	EFNA1 →	+0.759	+0.205	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034499 vs DIRC1 — HNSC

Explore this scatter interactively →