Late endosome to Golgi transport

Across TCGA cell cohorts, RNA activity of the Late endosome to Golgi transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC9A7, EFNB2, and DDR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC9A7 grouped by Late endosome to Golgi transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SLC9A7 →	-2.376	-1.903	.008	<.001	3	3
LUNG_NSCLC_LUAD	EFNB2 →	-2.556	-1.077	.001	.004	3	3
LUNG_NSCLC_LUAD	DDR1 →	-1.110	-0.932	<.001	.001	3	3
LUNG_NSCLC_LUAD	POLD3 →	+0.448	+1.142	.004	<.001	3	3
BREAST	KPNA3 →	+0.601	+0.795	.002	.005	3	3
BREAST	INTS6 →	+0.508	+0.827	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC9A7 by Late endosome to Golgi transport activity — BLOOD_Myeloma

Explore this box plot interactively →