Late endosome to Golgi transport

Across TCGA cell cohorts, RNA activity of the Late endosome to Golgi transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAVER1, VARS1, and GTF3C6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Late endosome to Golgi transport activity versus RAVER1 in LIVER (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAVER1 →	+1.122	+1.908	.003	<.001	3	5
LIVER	VARS1 →	+1.073	+1.605	<.001	.001	3	5
OVARY	GTF3C6 →	+0.943	+1.021	.002	.007	2	6
URINARY_TRACT	ACTR2 →	+0.700	+1.689	.007	.003	3	5
BLOOD_Myeloma	DAXX →	+0.747	+0.216	.002	.002	3	5
PANCREAS	PPIL1 →	+0.740	+0.940	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034499 vs RAVER1 — LIVER

Explore this scatter interactively →