Early endosome to Golgi transport

Across TCGA patient cohorts, RNA activity of the Early endosome to Golgi transport pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3_S348, SRRM2_S1112, and THBS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Early endosome to Golgi transport activity versus SORBS3_S348 in CCRCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SORBS3_S348 →	+0.662	+0.042	.003	.001	3	6
COAD	SRRM2_S1112 →	-0.589	-0.017	.009	.007	3	6
CCRCC	THBS3 →	+0.775	+0.057	<.001	<.001	3	6
PDAC	VIM →	+0.393	+0.037	<.001	.001	3	6
LUAD	COL1A1 →	+0.378	+0.030	.003	.003	3	6
BRCA	FAP →	+0.526	+0.035	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034498 vs SORBS3_S348 — CCRCC

Explore this scatter interactively →