Early endosome to Golgi transport

Across TCGA cell cohorts, RNA activity of the Early endosome to Golgi transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP7A, SH3RF3, and PTCHD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRP7A grouped by Early endosome to Golgi transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RRP7A →	+0.781	+1.417	<.001	.001	3	4
LUNG_NSCLC_LUSC	SH3RF3 →	-1.263	-1.044	.004	.009	3	4
CNS	PTCHD4 →	-0.812	-0.838	.005	<.001	3	4
SOFT_TISSUE	TFR2 →	+1.197	+1.276	.008	<.001	3	4
SKIN	INMT →	-1.082	-1.129	<.001	<.001	3	4
LIVER	BCORL1 →	-0.716	-1.663	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRP7A by Early endosome to Golgi transport activity — LUNG_SCLC

Explore this box plot interactively →