U4 snRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the U4 snRNA 3'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD3_S563, DNAJA1, and FUBP3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, U4 snRNA 3'-end processing activity versus BRD3_S563 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BRD3_S563 →	+1.166	+0.055	.001	.001	3	7
BRCA	DNAJA1 →	+0.220	+0.029	<.001	.001	3	7
LSCC	FUBP3 →	+0.171	+0.045	<.001	<.001	3	7
LSCC	MTA1_S576 →	+0.965	+0.074	<.001	<.001	3	7
GBM	SMU1 →	+0.199	+0.047	.001	.002	3	6
GBM	SPIN1 →	+0.268	+0.048	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034475 vs BRD3_S563 — OV

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