U4 snRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the U4 snRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAPPC6A, CEP152, and CKAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, U4 snRNA 3'-end processing activity versus TRAPPC6A in HNSC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAPPC6A →	-0.916	-0.106	.002	<.001	3	4
BRCA	CEP152 →	+0.432	+0.193	.001	<.001	3	3
BRCA	CKAP2 →	+0.395	+0.139	.003	<.001	3	3
BRCA	SASS6 →	+0.403	+0.119	.001	.004	2	4
BRCA	ART5 →	-0.457	-0.138	<.001	.001	3	3
PDAC	FAM66C →	-0.578	-0.166	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034475 vs TRAPPC6A — HNSC

Explore this scatter interactively →