U4 snRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the U4 snRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAGK, TRNT1, and GEMIN5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, U4 snRNA 3'-end processing activity versus NAGK in LUNG_NSCLC_LUSC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NAGK →	-1.290	-0.314	.009	<.001	2	7
KIDNEY	TRNT1 →	+0.720	+1.477	.002	.007	3	6
PANCREAS	GEMIN5 →	+1.555	+2.229	<.001	<.001	3	6
PANCREAS	NUP188 →	+1.221	+1.857	.001	<.001	3	6
URINARY_TRACT	SLC37A1 →	-2.420	-1.935	<.001	.001	3	5
URINARY_TRACT	CSNK1E →	+0.731	+1.492	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034475 vs NAGK — LUNG_NSCLC_LUSC

Explore this scatter interactively →