snRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the snRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFPQ, TTF2, and LHX4, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA 3'-end processing activity versus SFPQ in ACC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	SFPQ →	+0.922	+0.032	.006	.002	2	33
DLBC	TTF2 →	+1.430	+0.056	<.001	<.001	3	32
SCLC	LHX4 →	+0.729	+0.073	.001	<.001	3	32
UVM	PNISR →	+1.254	+0.034	<.001	<.001	3	32
UVM	ZRANB2 →	+1.384	+0.030	<.001	<.001	3	32
KIRC	KHDC4 →	+1.263	+0.057	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034472 vs SFPQ — ACC

Explore this scatter interactively →