snRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the snRNA 3'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2B, ACTL6A, and CPNE2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA 3'-end processing activity versus RRM2B in GBM (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RRM2B →	-0.349	-0.038	.003	.001	3	4
COAD	ACTL6A →	+0.132	+0.030	<.001	.002	3	4
LUAD	CPNE2 →	+0.300	+0.035	<.001	.001	3	4
CCRCC	RRBP1 →	-0.388	-0.036	<.001	<.001	3	4
BRCA	ATP9B →	-0.265	-0.028	.005	<.001	3	4
GBM	TMTC3 →	-0.394	-0.056	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034472 vs RRM2B — GBM

Explore this scatter interactively →