snRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the snRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CKAP2, SEPTIN4, and EGR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA 3'-end processing activity versus CKAP2 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CKAP2 →	+0.650	+0.246	.001	<.001	3	6
GBM	SEPTIN4 →	-0.706	-0.157	.004	.003	3	5
OV	EGR2 →	-1.160	-0.195	.005	.004	3	5
LUAD	EDNRA →	-0.711	-0.197	<.001	<.001	3	5
PDAC	TMEM119 →	-0.446	-0.125	.005	.001	3	5
GBM	ZWILCH →	+0.378	+0.160	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034472 vs CKAP2 — BRCA

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