snRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the snRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPBP1L1, CD3E, and EXOSC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPBP1L1 grouped by snRNA 3'-end processing-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GPBP1L1 →	-0.395	-0.180	.005	.004	3	4
BREAST	CD3E →	+0.053	+0.272	.005	<.001	3	4
BREAST	EXOSC5 →	-0.707	-0.217	.002	.002	2	5
BLOOD_Leukemia	LYRM7 →	+0.988	+0.405	<.001	.007	3	4
PANCREAS	DYNC2I1 →	-0.651	-0.310	.008	.005	1	5
PANCREAS	FAM210A →	+0.979	+0.353	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPBP1L1 by snRNA 3'-end processing activity — BREAST

Explore this box plot interactively →